About the nutrition of preterm neonates

While Human milk is the ideal nutrition for term infants, evidence indicates that the optimal development of preterm neonates require additional supplementation

Recommended
intake/kg/day(1, 2)
Early preterm milk
at 160 mL/kg/day
Term milk (3) at
160mL/kg/day
Energy 120 kcal ~ 107 kcal ~ kcal
Protein 3.5-4 (4.5) g Typically below 2.6g Invariably below 2.0 g
Calcium 120 mg ~ 50 mg ~ 50 mg
Phosphorus 60 mg ~9 mg ~ 9 mg

Apart from macro and micronutrients, human milk also contains over 1000 bioactive components, many of which are not found in bovine or other animal milk. These include growth and development factors, components with immunologic protective roles, enzymes, transport proteins and other factors.

Extensive studies showed that, compared to cow milk-based formulas, human milk provided protection against common complications of prematurity. Some of these protective effects showed clear dose-dependence.

Explore the science of human milk futher